Strategies for eliciting HIV-1 inhibitory antibodies
نویسندگان
چکیده
منابع مشابه
Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies
Human immunodeficiency virus type 1 (HIV-1) infection causes acquired immune deficiency syndrome (AIDS), a global epidemic for more than three decades. HIV-1 replication is primarily controlled through antiretroviral therapy (ART) but this treatment does not cure HIV-1 infection. Furthermore, there is increasing viral resistance to ART, and side effects associated with long-term therapy. Conseq...
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Methods We generated a mini-protein that is structurally rigid, yet efficiently recognized by 2F5, 4E10 and Z13e1. It contains the C-terminal 54 a.a. of gp41 ectodomain (gp41-54Q), which includes the HR2 and the MPER. A 6xHis tag at the C-terminus was used to attach gp41-54Q to Zn-chitosan, which served as an antigen carrier/adjuvant. Rabbits were immunized subcutaneously, 4 times, using two di...
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ژورنال
عنوان ژورنال: Current Opinion in HIV and AIDS
سال: 2010
ISSN: 1746-630X
DOI: 10.1097/coh.0b013e32833d2d45